Follow patients for signs and symptoms of respiratory depression and sedation. Adrenal insufficiency: Cases of adrenal insufficiency have been reported with opioid use, more often following greater than one month of use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately. What should I avoid while taking tolterodine Detrol? Squeeze the muscles that you use stop the flow of urine. cheap fludrocortisone online pharmacy fludrocortisone
Observational studies have demonstrated that concomitant use of opioid analgesics and benzodiazepines increases the risk of drug-related mortality compared to use of opioid analgesics alone. What is tolterodine Detrol? If any of these effects persist or worsen, tell your doctor or promptly. Then, if needed, she will order tests to get pictures of your kidneys and urinary tract. Demerol Injection contains meperidine, a substance with a high potential for abuse similar to other opioids including fentanyl, hydrocodone, hydromorphone, methadone, morphine, oxycodone, oxymorphone, and tapentadol.
You'll through this procedure. Think about stirring up your favorite drink from a powder mix. Take this medication with water.
Check the labels on all your medicines such as allergy or cough-and-cold products because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely. Long-term studies in animals to evaluate the carcinogenic potential of meperidine have not been conducted. If the level of pain increases after dosage stabilization, attempt to identify the source of increased pain before increasing the Demerol Injection dosage. If unacceptable opioid-related adverse reactions are observed, consider reducing the dosage. Adjust the dosage to obtain an appropriate balance between management of pain and opioid-related adverse reactions. fenofibrate
Monitor patients for signs of urinary retention or reduced gastric motility when Demerol Injection is used concomitantly with anticholinergic drugs. Serotonin syndrome: Cases of serotonin syndrome, a potentially life-threatening condition, have been reported during concomitant use of opioids with serotonergic drugs. Although the risk of addiction in any individual is unknown, it can occur in patients appropriately prescribed Demerol Injection. Addiction can occur at recommended dosages and if the drug is misused or abused. It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding. RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. Accumulation of normeperidine as in chronic use or possibly following introduction of a concomitant CYP3A4 inducer presents as excitatory syndrome including hallucinations, tremors, muscle twitches, dilated pupils, hyperactive reflexes, and convulsions. Drowsiness and confusion can increase the risk of falling. Demerol Injection should be used with caution in patients with atrial flutter and other supraventricular tachycardias because of a possible vagolytic action which may produce a significant increase in the ventricular response rate. The concomitant use of Demerol Injection and CYP3A4 or CYP2B6 inhibitors can increase the plasma concentration of meperidine, resulting in increased or prolonged opioid effects. Dosage should be adjusted according to the severity of the pain and the response of the patient. While subcutaneous administration is suitable for occasional use, intramuscular administration is preferred when repeated doses are required. If intravenous administration is required, dosage should be decreased and the injection made very slowly, preferably utilizing a diluted solution. Ureteroscopy: This procedure treats stones in the kidneys and ureters. Your doctor uses a thin, flexible scope to find and remove stones. Cases of adrenal insufficiency have been reported with opioid use, more often following greater than one month of use. Presentation of adrenal insufficiency may include non-specific symptoms and signs including nausea, vomiting, anorexia, fatigue, weakness, dizziness, and low blood pressure. If adrenal insufficiency is suspected, confirm the diagnosis with diagnostic testing as soon as possible. If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. Wean the patient off of the opioid to allow adrenal function to recover and continue corticosteroid treatment until adrenal function recovers. Other opioids may be tried as some cases reported use of a different opioid without recurrence of adrenal insufficiency. The information available does not identify any particular opioids as being more likely to be associated with adrenal insufficiency.
First, she will get a medical history and examine you. If there's a blockage, you may need surgery. Before you take tolterodine, tell your doctor if you have kidney or liver disease, glaucoma, myasthenia gravis, or a personal or family history of "Long QT syndrome. What are the possible side effects of tolterodine Detrol LA? Swallow Detrol LA extended-release capsules whole. Do not break, crush, or chew before swallowing. Prolonged use of Demerol Injection during pregnancy can result in withdrawal in the neonate. Neonatal opioid withdrawal syndrome, unlike opioid withdrawal syndrome in adults, may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. Observe newborns for signs of neonatal opioid withdrawal syndrome and manage accordingly. Pfizer also has programs that provide eligible patients with insurance, support assistance, and medicines at a savings. Contact Pfizer RxPathways for details 844-989-7284. Use Detrol LA extended-release capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions. This program provides uninsured patients with savings on their prescriptions at the pharmacy. Demerol Injection should not be used for treatment of chronic pain. Read the Patient Information Leaflet if available from your pharmacist before you start using tolterodine and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Ask your health care provider any questions you may have about how to use Detrol LA extended-release capsules. ezetimibe
Candesartan belongs to a class of drugs called angiotensin receptor blockers ARBs. It works by relaxing vessels so can flow more easily. The potential for these risks should not, however, prevent the proper management of pain in any given patient. Patients at increased risk may be prescribed opioids such as Demerol Injection, but use in such patients necessitates intensive counseling about the risks and proper use of Demerol Injection along with intensive monitoring for signs of addiction, abuse, and misuse. If you are taking this once daily and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Meperidine hydrochloride is an opioid agonist with multiple actions qualitatively similar to those of morphine; the most prominent of these involve the central nervous system and organs composed of smooth muscle. The principal actions of therapeutic value are analgesia and sedation. This medicine may cause bleeding. Daily use of alcohol while using this medicine may increase your risk for stomach bleeding. While serious, life-threatening, or fatal respiratory depression can occur at any time during the use of Demerol Injection, the risk is greatest during the initiation of therapy or following a dosage increase. Monitor patients closely for respiratory depression, especially within the first 24 to 72 hours of initiating therapy with and following dosage increases of Demerol Injection. Do not crush, chew, break, or open a controlled-release capsule. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time. Where can I get more information? The findings cannot be clearly attributed to maternal toxicity.
Store Detrol LA extended-release capsules at room temperature, between 68 and 77 degrees F 20 and 25 degrees C. Brief storage at temperatures between 59 and 86 degrees F 15 and 30 degrees C is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Detrol LA extended-release capsules out of the reach of children and away from pets. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. If you do not take the same dose each day or if you take this medication every other day, ask your doctor or what you should do if you miss a dose. The dose should be titrated to the needs of the patient and will depend on the premedication and type of anesthesia being employed, the characteristics of the particular patient, and the nature and duration of the operative procedure. Elderly patients should usually be given meperidine at the lower end of the dose range and observed closely. The most frequently observed adverse reactions include lightheadedness, dizziness, sedation, nausea, vomiting, and sweating. These effects seem to be more prominent in ambulatory patients and in those who are not experiencing severe pain. In such individuals, lower doses are advisable. Some adverse reactions in ambulatory patients may be alleviated if the patient lies down. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. It is not known whether tolterodine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. It repositions the urethra to help reduce leakage. Overdose symptoms may include dry mouth, blurred vision, and fast heartbeat. Detrol LA extended-release capsules may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Detrol LA extended-release capsules with caution. What should I discuss with my healthcare provider before taking tolterodine Detrol? Because the duration of opioid reversal is expected to be less than the duration of action of meperidine in Demerol Injection, carefully monitor the patient until spontaneous respiration is reliably re-established. If the response to an opioid antagonist is suboptimal or only brief in nature, administer additional antagonist as directed by the product's prescribing information. Side Effects List Detrol LA side effects by likelihood and severity. Tell your doctor if your condition does not improve or if it worsens. purchase galantamine indication
Individually titrate Demerol Injection to a dose that provides adequate analgesia and minimizes adverse reactions. Physical dependence results in withdrawal symptoms after abrupt discontinuation or a significant dosage reduction of a drug. The concomitant use of acyclovir may increase the plasma concentrations of meperidine and its metabolite, normeperidine. Cut back on sodium and salty foods: Lots of sodium can raise calcium levels in your urine. And that can cause stones to form. Tolterodine reduces spasms of the bladder muscles. Overestimating the Demerol Injection dosage when converting patients from another opioid product can result in a fatal overdose with the first dose.
Older adults may be more sensitive to the side effects of this drug, especially QT prolongation see above drowsiness, confusion, constipation, or trouble urinating. Drowsiness and confusion can increase the risk of falling. This medication is not recommended for use in children younger than 1 year due to increased risk of side effects. For these reasons, FAERS case reports cannot be used to calculate incidence or estimates of risk for a particular product or compare risks between products. In clinical studies reported in the literature, changes in several pharmacokinetic parameters with increasing age have been observed. The initial volume of distribution and steady-state volume of distribution may be higher in elderly patients than in younger patients. The free fraction of meperidine in plasma may be higher in patients over 45 years of age than in younger patients. Assess each patient's risk for opioid addiction, abuse, or misuse prior to prescribing Demerol Injection, and monitor all patients receiving Demerol Injection for the development of these behaviors and conditions. What happens if I miss a dose Detrol? Read the Patient Information Leaflet if available from your before you start taking and each time you get a refill. If you have any questions, ask your doctor or pharmacist. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Drug addiction is a cluster of behavioral, cognitive, and physiological phenomena that develop after repeated substance use and includes a strong desire to take the drug, difficulties in controlling its use, persisting in its use despite harmful consequences, a higher priority given to drug use than to other activities and obligations, increased tolerance, and sometimes a physical withdrawal. tanabe norfloxacin
Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. Detrol LA extended-release capsules are to be used only by the patient for whom it is prescribed. Do not share it with other people. You need to get the condition treated. If your bladder can't empty, that can lead to infections and other problems. The dose of Demerol Injection should be proportionately reduced usually by 25 to 50 percent when administered concomitantly with phenothiazines and many other tranquilizers since they potentiate the action of Demerol Injection. This product may increase your potassium levels. Before using potassium or salt substitutes that contain potassium, consult your doctor or pharmacist. Blurred vision; constipation; dizziness; drowsiness; dry eyes; dry mouth; headache; indigestion; stomach pain. Discuss the risks and benefits with your doctor. The half-life of meperidine is 2 to 5 hours, and the half-life of normeperidine is 15 to 30 hours. How should I take tolterodine Detrol LA? This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects.
Do not stop taking this medication without consulting your doctor. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. Take this by with or without food as directed by your doctor, usually once or twice daily. Inform your doctor if your condition persists or worsens. Demerol Injection exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. They also stimulate prolactin, growth hormone GH secretion, and pancreatic secretion of insulin and glucagon. The meperidine in Demerol Injection may increase the frequency of seizures in patients with seizure disorders, and may increase the risk of seizures occurring in other clinical settings associated with seizures. Monitor patients with a history of seizure disorders for worsened seizure control during Demerol Injection therapy. The following adverse reactions associated with the use of meperidine were identified in clinical studies or postmarketing reports. Because some of these reactions were reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. FDA pregnancy category C. It is not known whether tolterodine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Meperidine is known to be substantially excreted by the kidney, and the risk of adverse reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function. Cystine stones: This is the least common type. Once you get a cystine stone, there is a chance that you may have one again. You inherit the possibility of getting them from your parents, both of whom would have to have the same type of genetic disorder. This medication may lower your ability to fight infections. This may make you more likely to get a serious rarely fatal infection or make any infection you have worse. ampicillin
Gastrointestinal. Dry mouth, constipation, biliary tract spasm. The safety and effectiveness of meperidine in pediatric patients has not been established. Literature reports indicate that meperidine has a slower elimination rate in neonates and young infants compared to older children and adults. Neonates and young infants may also be more susceptible to the effects, especially the respiratory depressant effects. If meperidine use is contemplated in neonates or young infants, any potential benefits of the drug need to be weighed against the relative risk of the patient. Injections and surgery. Shots to bulk up your urethral area may help. In more extreme cases, you may need surgery. One procedure pulls the bladder back up to a more normal position, relieving the pressure and leakage. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Demerol Injection, like other opioids, can be diverted for non-medical use into illicit channels of distribution. Careful record-keeping of prescribing information, including quantity, frequency, and renewal requests, as required by state and federal law, is strongly advised. Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. These help to strengthen the pelvic floor after childbirth. They also help prevent stress incontinence. Best of all, you can do Kegels anytime, anywhere. Opioids cross the placenta and may produce respiratory depression and psycho-physiologic effects in neonates. An opioid antagonist, such as naloxone, must be available for reversal of opioid-induced respiratory depression in the neonate. Demerol Injection is not recommended for use in pregnant women during or immediately prior to labor, when other analgesic techniques are more appropriate. Opioid analgesics, including Demerol Injection, can prolong labor through actions which temporarily reduce the strength, duration, and frequency of uterine contractions. However, this effect is not consistent and may be offset by an increased rate of cervical dilation, which tends to shorten labor. Monitor neonates exposed to opioid analgesics during labor for signs of excess sedation and respiratory depression. Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Monitor for signs of opioid withdrawal. Detrol LA extended-release capsules works best if it is taken at the same time each day. Prescription drug abuse is the intentional non-therapeutic use of a prescription drug, even once, for its rewarding psychological or physiological effects. If concomitant use of acyclovir and Demerol Injection is necessary, monitor patients for respiratory depression and sedation at frequent intervals. Marked mydriasis rather than miosis may be seen due to hypoxia in overdose situations. Elderly patients aged 65 years or older may have increased sensitivity to meperidine. In general, use caution when selecting a dosage for an elderly patient, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other drug therapy.
Demerol Injection is achieved. Similarly, discontinuation of a CYP3A4 inducer, such as rifampin, carbamazepine, and phenytoin, in DEMEROL-Injection treated patients may increase meperidine plasma concentrations and prolong opioid adverse reactions. It is unknown if this drug passes into milk. Consult your doctor before -feeding. Formal reproductive and developmental toxicology studies for meperidine have not been completed. It is not known whether this drug passes into milk. Consult your doctor before -feeding. For certain products of this drug, an empty tablet shell may appear in your stool. This is harmless. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. How should I take tolterodine Detrol? In patients with pheochromocytoma, meperidine has been reported to provoke hypertension. Meperidine is contraindicated in patients who are receiving monoamine oxidase MAO inhibitors or those who have recently received such agents. Therapeutic doses of meperidine have occasionally precipitated unpredictable, severe, and occasionally fatal reactions in patients who have received such agents within 14 days. The mechanism of these reactions is unclear, but may be related to a preexisting hyperphenylalaninemia. Some have been characterized by coma, severe respiratory depression, cyanosis, and hypotension, and have resembled the syndrome of acute narcotic overdose. Serotonin syndrome with agitation, hyperthermia, diarrhea, tachycardia, sweating, tremors and impaired consciousness may also occur. In other reactions the predominant manifestations have been hyperexcitability, convulsions, tachycardia, hyperpyrexia, and hypertension. Prolonged use of opioid analgesics during pregnancy may cause neonatal opioid withdrawal syndrome. Available data with Demerol Injection are insufficient to inform a drug-associated risk for major birth defects and miscarriage. Formal animal reproduction studies have not been conducted with meperidine. Even if you have a kidney stone, you may not have any symptoms -- that is, until the stone goes on the move. generic albendazole pharmacy at home
Flecainide can affect your heart's rhythm. Other drugs can have the same effect. The dosage is based on your medical condition and response to treatment. Demerol Injection contains meperidine, a Schedule II controlled substance. Methylprednisolone may make you dizzy. not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. This means you may dribble urine. Do 3 or 4 sets daily. Alternatively, consider the use of non-opioid analgesics in these patients. If you get a kidney stone, you are in danger of getting more later in life.
Because of these risks, reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate. The minimum effective analgesic concentration will vary widely among patients, especially among patients who have been previously treated with potent agonist opioids. Adverse outcomes in pregnancy can occur regardless of the health of the mother or the use of medications. Store at room temperature away from moisture and heat. This medication may cause to not work as well. Live may cause serious problems such as infection if given while you are using this medication. This may interfere with certain laboratory tests such as possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug. This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit alcoholic beverages. If Demerol Injection is abruptly discontinued in a physically-dependent patient, a withdrawal syndrome may occur. Some or all of the following can characterize this syndrome: restlessness, lacrimation, rhinorrhea, yawning, perspiration, chills, myalgia, and mydriasis. Other signs and symptoms also may develop, including: irritability, anxiety, backache, joint pain, weakness, abdominal cramps, insomnia, nausea, anorexia, vomiting, diarrhea, or increased blood pressure, respiratory rate, or heart rate. Struvite stones: Infections, especially in the urinary tract, can cause you to have this kind of stone. Shock wave lithotripsy: This is the most common procedure for kidney stones in the United States. It uses shock waves, which can blast the stone into little pieces. Then, the smaller pieces can more easily be passed in your urine. discount doxylamine kada
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In case of overdose, priorities are the reestablishment of a patent and protected airway and institution of assisted or controlled ventilation, if needed. Employ other supportive measures including oxygen and vasopressors in the management of circulatory shock and pulmonary edema as indicated. Cardiac arrest or arrhythmias will require advanced life-support techniques. This is a long-acting form of that is used to treat and urinary conditions. QTdrugs List, AZCERT, Inc. Report prolonged or to your doctor. zithromax campus zithromax
Symptoms may include difficulty breathing; difficulty urinating; dilated pupils; dry mouth; excitation; fast heartbeat; hallucinations; seizures. What is the most important information I should know about tolterodine Detrol? The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using tolterodine, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems heart failure, slow heartbeat, QT prolongation in the EKG family history of certain heart problems QT prolongation in the EKG, sudden cardiac death.
Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time each day. If your kidney stone is small, you may be able to get rid of it when you pee. First, you complete a chart of the times you pee and the times you leak. You observe patterns and then plan to empty your bladder before an accident would happen. You can also "retrain" your bladder, gradually increasing the time between bathroom visits. Kegel exercises are also helpful. asten.info cefpodoxime
This medication contains tolterodine. Do not take Detrol or Detrol LA if you are allergic to tolterodine or any ingredients contained in this drug. This information should not be used to decide whether or not to take Detrol LA extended-release capsules or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Detrol LA extended-release capsules. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Detrol LA extended-release capsules. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Detrol LA extended-release capsules.